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KMID : 1128320150130010017
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Electrolytes & Blood Pressure
2015 Volume.13 No. 1 p.17 ~ p.21
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Loop Diuretics in Clinical Practice
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Oh Se-Won
Han Sang-Youb
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Abstract
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Diuretics are commonly used to control edema across various clinical fields. iuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased rinary sodium and water excretion. Loop diuretics are the most potent iuretics. In this article, we review five important aspects of loop diuretics, in articular furosemide, which must be considered when prescribing this medicine: 1) oral versus intravenous treatment, (2) dosage, (3) continuous versus olus infusion, (4) application in chronic kidney disease patients, and (5) side ffects. The bioavailability of furosemide differs between oral and intravenous herapy. Additionally, the threshold and ceiling doses of furosemide differ according o the particular clinical condition of the patient, for example in patients ith severe edema or chronic kidney disease. To maximize the efficiency of furosemide, a clear understanding of how the mode of delivery will impact bioavailability and the required dosage is necessary.
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KEYWORD
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Loop diuretics, Furosemide, Chronic kidney disease
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